ESTUDO TEÓRICO E EXPERIMENTAL DE ESTRUTURA E REATIVIDADE RELACIONADO AO METABOLISMO E TOXICIDADE DO PARACETAMOL

THEORETICAL AND EXPERIMENTAL STUDY OF STRUCTURE REACTIVITY RELATED TO METABOLISM TOXICITY PARACETAMOL. An experimental and theoretical approach on oxidative metabolism of paracetamol was applied for the pharmaceutical chemistry learning. Classical reactions, functional group identification, structural parameter, chemical reactivity using frontier orbitals Fukui index were used explaining main products between N-acetyl-p-benzosemiquinone (NAPQI) thiolic compounds. The chemoprotection mechanisms by N-acetyl-cysteine high dosage are consistent with results. methods also described relationship quinone-imine system induced-toxicity Michael reaction. These results can be in teaching